Want to end TB? Diagnose and treat all forms of the disease
Tuberculosis should be a specter of the past, something only our great-grandparents feared and died of. Alas, although almost all cases of TB today are both preventable and treatable, several different...
View ArticleTuberculosis—the disease of antiquity
In the time it takes to read this article, half a dozen people will have died from tuberculosis (TB).
View ArticleTuberculosis vaccine safe for teens with Schistosoma parasite
Of the millions of people at risk for contracting tuberculosis each year, many are already infected with helminths, parasitic worms including Schistosoma flatworms. In some cases, parasite infections...
View ArticleA defence mechanism that can trap and kill TB bacteria
A natural mechanism by which our cells kill the bacterium responsible for tuberculosis (TB) has been discovered by scientists at the Francis Crick Institute, which could help in the battle against...
View ArticleDartmouth tuberculosis vaccine passes important milestone
Investigators at Dartmouth's Geisel School of Medicine announced that two new studies of DAR-901, their investigational vaccine against tuberculosis (TB), have moved it to the forefront of new vaccines...
View ArticleMultidrug-resistant TB set to increase through 2040
(HealthDay)—Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are expected to increase through 2040, according to a study published online May 9 in The Lancet Infectious...
View ArticleTB bacteria evolve at alarming rate
Researchers from the Vavilov Institute of General Genetics of the Russian Academy of Sciences (VIGG) and the Moscow Institute of Physics and Technology (MIPT) have established a catalog of mutations in...
View ArticleScientists develop a quick, cheap and portable test for diagnosing tuberculosis
A microchip-based test developed by A*STAR researchers can diagnose tuberculosis in 15 minutes. The test meets the speed, cost, accessibility and disposal standards recommended by the World Health...
View ArticleOrganic compound found in red wine boosts the body's ability to fight...
An organic compound found in grape skins can stimulate the mouse immune system to fight even the most persistent tuberculosis strains. Such immune-based therapies, commonly used to treat cancer, could...
View ArticleTuberculosis bacterium may undermine immune regulation to drive disease...
Mycobacterium tuberculosis (Mtb)—may disrupt human immune system regulation processes to promote destruction of lung tissue, according to new research published in PLOS Pathogens.
View ArticleBacteria from cystic fibrosis patient could help thwart antibiotic-resistant TB
The number of drug-resistant tuberculosis (TB) cases is rising globally. But a newly discovered natural antibiotic—produced by bacteria from the lung infection in a cystic fibrosis patient—could help...
View ArticleBacteria from cystic fibrosis patient could help fight antibiotic-resistant TB
A newly discovered antibiotic, produced by bacteria from a cystic fibrosis patient, could be used to treat cases of drug-resistant tuberculosis (TB). This is the finding of a team of scientists from...
View ArticleNovel metabolic mechanism holds potential as tuberculosis drug target
Researchers from the Cornell University College of Veterinary Medicine, New York, have discovered a key metabolic mechanism in Mycobacterium tuberculosis (Mtb) bacteria, which presents as a novel drug...
View ArticleA genetic variation may increase tuberculosis susceptibility
Researchers have shown that a single nucleotide change in a gene that affects production of hepcidin—a peptide involved in inflammation, immunity, and control of iron levels—is associated with greater...
View ArticleChange in conversion definition may improve TB detection
(HealthDay)—A change of QuantiFERON-TB interferon (IFN)γ values from 0.7 IU/mL is associated with an increased incidence in the rate of tuberculosis, according to a study published online July 24 in...
View ArticleStudent discovers tuberculosis DNA in dental plaque of Smithsonian's...
In a collection of historic skeletal remains at the Smithsonian, microscopic signs of a serious contagion lurk in an intriguing place in a sample of individuals from 100 years ago.
View ArticleTuberculosis drug may work better than others in its class
Treatment of tuberculosis involves a combination of several drugs, sometimes including drugs from a class known as fluoroquinolones. Using computer simulations, scientists have shown that the...
View ArticleWhat role do genome variations play in tuberculosis?
Tuberculosis is caused by Mycobacterium tuberculosis. In 2016, this was the most common causative pathogen for death by infectious diseases. Therefore, investigating the biology of infection and...
View ArticleAssay can ID M. tuberculosis resistance mutations
(HealthDay)—An automated molecular assay can detect Mycobacterium tuberculosis with resistance to drugs directly from sputum specimens, according to a study published in the Sept. 14 issue of the New...
View ArticleHow tuberculosis bacteria hide in the body
Tuberculosis bacteria hide in the very cells that would normally kill them. Now we know more about how they evade recognition. Tuberculosis affects millions of people worldwide. Treatment is often...
View ArticleHIV: The benefits of prophylaxis of tuberculosis are confirmed
A long-term follow-up study in the ANRS TEMPRANO trial confirms that tuberculosis chemoprophylaxis in HIV-infected people is more than ever relevant in resource-limited countries. This prophylactic use...
View ArticleSolving of a decade long mystery could help in fight against tuberculosis
Scientists have solved a decade-old mystery that could eventually lead to the development of earlier treatments for one of the world's deadliest diseases, which affects up to 2 billion people.
View ArticleCompletion likely with self-administration of TB treatment
(HealthDay)—Most people complete treatment for latent tuberculosis (TB) without direct observation, according to a study published online Nov. 6 in the Annals of Internal Medicine.
View ArticleProgression from infection to pulmonary tuberculosis follows distinct timeline
Researchers have uncovered a sequence of biological processes that occur in humans infected with the bacterium Mycobacterium tuberculosis as the infection progresses to pulmonary tuberculosis,...
View ArticleGastric acid suppressant lansoprazole may target tuberculosis
A cheap and widely used drug, used to treat conditions such as heartburn, gastritis and ulcers, could work against the bacteria that cause tuberculosis (TB), according to new research from UCL and the...
View ArticleThe effectiveness of strategies to improve people's access to treatment for...
In a new Cochrane Review, researchers from Tanzania working with colleagues in LSTM have evaluated the effectiveness of strategies to improve people's access to treatment for tuberculosis (TB).
View ArticleDecoding tuberculosis—using analysis to better understand disease, develop...
Mycobacterium tuberculosis (Mtb) is the causative agent of the serious lung disease, tuberculosis, that is widespread throughout the world. About one-third of the human population is infected with...
View ArticleUrine test developed to test for tuberculosis
(Medical Xpress)—An international team of researchers has developed a urine test that can be used to detect tuberculosis (TB) in human patients. In their paper published in Science Translational...
View ArticleCluster of resistant tuberculosis pathogen discovered
Between February and November 2016, the Institute of Medical Microbiology at the University of Zurich discovered a multidrug-resistant Mycobacterium tuberculosis in eight refugees arriving in Europe...
View ArticleBovine tuberculosis shows genetic diversity throughout Africa
Bovine tuberculosis (BTB) is an infectious disease caused by Mycobacterium bovis that affects cattle as well as other animals and humans. Now, by combining genotyping M. bovis samples from cows across...
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